Knob Into Hole - Other Classified Ads in Walnut

Knob Into Hole

SaleSpider Left Classified Main Image
The knobs-into-holes technique is suitable for heterodimerization immunoglobulin heavy (H) chains with amino acid (AA) changes, which can overcome the mispairing problem. In order to overcome the impurity problem in tri-functional antibody production process, experts from Creative Biolabs introduce a knob into the CH3 of one antibody and a corresponding hole into the CH3 of the other antibody via the alteration of AA respectively. We then co-transfect these constructs encoding all four chains either into E.coli or mammalian cells such as human embryonic kidney (HEK) cells. We can also provide glycosylated, functional and competent heterodimeric antibodies after the expression step in mammalian host.
September 2, 2016
Walnut, California

Share This Classified With Your Social Networks

Subscribe to this RSS Feed

Member Spotlight

Carl L Maynard Jr Icon
Carl L Maynard Jr
Global Domains International Inc.

Business Spotlight

Pest Control of Glendale Icon
Pest Control Of Glendale
knob into hole