Chaperone-mediated Autophagy - Other Classified Ads in Shirley
Autophagy is an intracellular phenomenon that is activated under conditions of intracellular and extracellular modalities of stress such as endoplasmic (ER) stress or nutrient deprivation/starvation. This phenomenon is characterized by the presence of double membrane cytosolic vacuoles called ?autophagosomes.? The autophagosomes have been documented to engulf and sequester cytosolic organelles under conditions of stress and ultimately fuse with the lysosomes. The lysosomal hydrolases then breakdown the organelles and recycle the proteins and amino acids into the cell machinery for its survival in nutrient compromised conditions. Autophagy has been documented to be a highly conserved phenomenon from yeast to mammals. A common unified nomenclature has been proposed to name the proteins involved in the process of autophagy. The genes involved in mammalian autophagy are denoted as ?ATG-genes? while the proteins are depicted as ?atg-proteins?. Also a very recent report suggests and outlines the guidelines for the interpretation and the use of assays used to study autophagy in higher eukaryotes. Thus the studies in atuophagy are gaining momentum and becoming more structured.