SMB technology is a process utilizing several columns to achieve high productivity. It is versatile for the preparation of chiral drugs and a large number of other APIs. SMB is mainly used for binary separations such as enantiomeric purifications, and it can also be used to achieve chemical purifications.
SFC technology is liquid chromatography utilizing supercritical CO2 as a replacement solvent for traditional non-polar organic solvents. It can be used for purification of materials with poor solution stability. Supercritical liquid has characters of both gas and liquid, thus making it low viscosity. SFC is suitable for small to larger separation.
HPLC is the most renowned analytical technique used in the fine chemical and pharmaceutical industries. Chiral batch HPLC is a simple and fast way to obtain small scale samples using 1-10 cm I.D. columns. Over 90% of racemic small molecules can be separated by HPLC at small scales.